Exhibit 32.1 Globalwise Investments, Inc. CERTIFICATION OF PERIODIC REPORT Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 18 U.S.C. Section 1350 The undersigned officer of Globalwise Investments, Inc. certifies pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that: .. the annual report on Form 10-KSB of the Company for the year ended December 31, 2004, fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and .. the information contained in the Form 10-KSB fairly presents, in all material respects, the financial condition and results of operations of the Company. Date: March 24, 2005 /s/ Donald R. Mayer ____________________________________ Donald R. Mayer Principal Executive Officer Principal Financial Officer