Exhibit 32.1


                   Globalwise Investments, Inc.

                 CERTIFICATION OF PERIODIC REPORT
    Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002
                      18 U.S.C. Section 1350

The undersigned executive officer of Globalwise Investments, Inc. (the
"Company") certifies pursuant to Section 906 of the Sarbanes-Oxley Act of 2002
that:

..    the quarterly report on Form 10-QSB of the Company for the quarter ended
     September 30, 2005, fully complies with the requirements of Section 13(a)
     or 15(d) of the Securities Exchange Act of 1934; and

..    the information contained in the Form 10-QSB fairly presents, in all
     material respects, the financial condition and results of operations of
     the Company.



                            /s/ Donald R. Mayer
Date: 11-7-05               --------------------------------------------
                            Donald R. Mayer
                            Principal Executive Officer
                            Principal Financial Officer