Exhibit 32.1



GLOBALWISE INVESTMENTS, INC.


CERTIFICATION OF PERIODIC REPORT

Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

18 U.S.C. Section 1350


The undersigned executive officer of Globalwise Investments, Inc. certifies pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 that:


a.

the quarterly report on Form 10-Q of Globalwise Investments, Inc. for the quarter ended March 31, 2011 fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and


b.

the information contained in the Form 10-Q fairly presents, in all material respects, the financial condition and results of operations of Globalwise Investments, Inc.




Date: April 29, 2011



/s/ Donald R. Mayer

Donald R. Mayer

Principal Executive Officer

Principal Financial Officer